| Successful treatment with Bumex tablets following instances of allergic reactions to furosemide suggests a lack of cross-sensitivity | Anticoagulants Interaction studies in humans have shown Bumex to have no effect on warfarin metabolism or on plasma prothrombin activity |
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| The potential exists, however, and must be considered a risk of intravenous therapy, especially at high doses, repeated frequently in the face of renal excretory function impairment |
Parenteral Administration Bumetanide injection may be administered parenterally intravenously and intramuscularly to patients in whom gastrointestinal absorption may be impaired or in whom oral administration is not practical.
12| Several pharmacokinetic studies have shown that bumetanide, administered orally or parenterally, is eliminated rapidly in humans, with a half-life of between 1 and 1½ hours | One or more of these adverse reactions have been reported in approximately 4 |
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| In a population of neonates receiving bumetanide for volume overload, mean serum clearance rates were 2 | A single dose of 0 |
These effects were associated with maternal weight reductions noted during dosing.